A Study to Investigate LYL797 in Adults With Solid Tumors

Exclusion Criteria

• •Prior treatment with any adoptive T-cell therapy or other anti-ROR1 therapy
• •Prior solid organ transplantation
• •Active, untreated brain metastasis or leptomeningeal disease; however, stable, treated brain metastases are allowed
• •Untreated or active infection at the time of screening or leukapheresis
• •HIV-positive, HTLV-1-positive, active acute HAV, acute or chronic HBV or HCV, or active tuberculosis
• •Impaired cardiac function or clinically significant cardiac disease
• •Uncontrolled pleural effusion, pericardial effusion, ascites requiring recurrent drainage procedures (once monthly or more frequent), or lymphangitis carcinomatosis
• •History of interstitial pneumonitis or pulmonary fibrosis.
• •Systemic corticosteroids or other immunosuppressive medications within 14 days of leukapheresis
• •Pregnant or lactating/nursing women