Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Johns Hopkins Bloomberg School of Public Health
With
Duke University
Patient-Centered Outcomes Research Institute
National Institute of Mental Health (NIMH)
Age
18–65
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Duke University Health System Electronic Health Record (EHR) System and Johns Hopkins Health System EHR System
All patients prescribed any Duloxetine or Vortioxetine in the health systems between 01/01/2015 - 12/31/2021.
AND from patients with at least 1-year historical EHR data (burn-in period) without prescribing any of the two medications. During the burn-in period, patients should have at least one encounter in the system, and with no encounters during that time frame when they were prescribed Duloxetine or Vortioxetine.
AND patients age 18-65 years old at baseline.
Male or female
Age 18 years or older
Major depressive episode according to Diagnostic and Statistical Manual of Mental Disorders, 4th edition, Text Revision (DSM-IV-TR) classification code 296.3x
Montgomery-Asberg Depression Rating Scale (MADRS) total score ≥ 26
Clinical Global Impression - Severity (CGI-S) scale score ≥ 4
You may not be if
\- Patients prescribed both Duloxetine and Vortioxetine at baseline would be removed.
