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ATP Level and Cough Sensitivity to ATP in Subjects With Refractory/Unexplained Chronic Cough | Clinical Trials | Clareo Health

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ATP Level and Cough Sensitivity to ATP in Subjects With Refractory/Unexplained Chronic Cough

ATP Level in Induced Sputum and Cough Sensitivity to ATP in Subjects With Refractory/Unexplained Chronic Cough

NCT05265871•Kefang Lai

View on ClinicalTrials.gov

Summary

This is a cross-sectional study to investigate ATP level in induced sputum and cough sensitivity to ATP in subjects with refractory/unexplained chronic cough. 60 patients with refractory/unexplained chronic cough and 30 matched healthy controls were recruited. Demographic data, clinical characteristic, cough sacles and medical history records were collected. Cough chanllage(ATP and capsaicin) and ATP measurement in sputum were conducted.The difference of sputum ATP level between patients and control and the correlation between sputum ATP level and cough sensitivity to ATP were analyzed.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•1. ≥18 years old
•2. cough as sole symptom lasting ≥6 months
•3. cough visual analogue score ≥30mm
•4. diagnosed as RCC/UCC according to guidelines

Exclusion Criteria

•1. smoking currently or in the past 6 months, or a smoking history of \>20 pack-year
•2. a forced expiratory volume in 1 second/forced vital capacity ratio \<70%;
•3. use of inhaled/oral corticosteroid, bronchodilators, anti-allergic medicine, antitussive medicine or anti-reflux treatment in the past 1 week;
•4. a history of acute respiratory infection in the past 4 weeks;
•5. a history of severe disease (cancer, acute coronary syndrome and so on).
•1. smoking currently or in the past 6 months, or a smoking history of \>20 pack-year
•2. a forced expiratory volume in 1 second/forced vital capacity ratio \<70%
•3. a history of acute respiratory infection in the past 4 weeks
•4. posstive findings of chest radiography
•5. a history of chronic respiratory disease and allergic disease
+1 more criteria

Locations (1)

Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University

Guangzhou, Guangdong, China

Key Dates

Start Date

May 16, 2022

Primary Completion Date

January 24, 2024

Completion Date

January 24, 2024

Last Updated

May 11, 2025

Enrollment

131

ACTUAL participants

Conditions

Refractory/Unexplained Chronic Cough