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Exploring Mechanisms of Massed Cognitive Processing Therapy | Clinical Trials | Clareo Health

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Exploring Mechanisms of Massed Cognitive Processing Therapy

Exploring Mechanisms of Massed Cognitive Processing Therapy: A Randomized Controlled Trial

NCT05265039•Rush University Medical Center

Summary

The overall goal of this randomized controlled trial with partial crossover is to compare the effectiveness of 1-week virtual massed Cognitive Processing Therapy (CPT) to 5-day virtual relaxation training (RT) with regard to their ability to reduce posttraumatic stress disorder (PTSD) symptoms. Specifically, this study is designed to 1) examine changes in PTSD symptoms during and following the respective intervention, and 2) explore possible psychological treatment mechanisms, including cognitive control, inhibition, self-efficacy, and memory, and 3) examine possible moderators of treatment success (e.g. neuropsychological factors).

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Are fluent in English
•Have experienced a Criterion A traumatic event during their lifetime
•Have a PTSD diagnosis verified via the Clinician Administered PTSD Scale for DSM
•Are interested in receiving evidence-based treatment (CPT) for PTSD and able to attend either 10 therapy sessions over the course of one week (5 days) or are interested and able to complete 5 relaxation training sessions over the course of one week (5 days)
•Are willing and able to complete self-report measures and clinician-rated assessments at multiple time points over the course of the study
•Reside in the state of Illinois during the course of treatment

Exclusion Criteria

•1. The traumatic event occurred in the past month
•2. They are currently suicidal or homicidal (i.e., plan and intent)
•3. They have unmanaged psychosis or mania
•4. They have not been on a stable dose of psychotropic medication for at least one month by the time of the baseline assessment
•5. They have completed an evidence-based cognitive behavioral PTSD treatment (e.g., Cognitive Processing Therapy or Prolonged Exposure) in the past 3 months or are currently receiving an evidence-based PTSD treatment
•6. They have an intellectual disability or significant cognitive impairment that would prevent them from engaging in CPT
•7. They have a serious or unstable medical illness or instability for which hospitalization may be likely within the next year
•8. They have an active substance use disorder (within the past 3 months) that would require immediate medical observation if substance use was discontinued (i.e., potential lethality)
•9. They are involved with current legal actions related to the traumatic event that is anticipated to be targeted during treatment
•10. They have a visual or auditory impairment that would prevent them from fully participating in study activities
+1 more criteria

Locations (1)

Rush University Medical Denter

Chicago, Illinois, United States

Key Dates

Start Date

April 26, 2022

Primary Completion Date

September 30, 2025

Completion Date

December 31, 2026

Last Updated

February 27, 2026

Enrollment

140

ESTIMATED participants

Conditions

PTSD

Interventions

Cognitive Processing Therapy

BEHAVIORAL

Relaxation Training

BEHAVIORAL

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 27, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Exploring Mechanisms of Massed Cognitive Processing Therapy

Inclusion Criteria

Exclusion Criteria

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