Observational Study for Assessing Treatment and Outcome of Patients With Primary Brain Tumours Using cIMPACT-NOW and 2021 WHO Classification

Inclusion Criteria

• •Age ≥ legal age of consent
• •Newly diagnosed or recurrent primary brain tumours within one of the 17 cohorts of interest
• •Archival tumour tissue from primary tumour available at the site. Representative tissue from first surgery is preferred, but tissue from surgery for recurrence is allowed. Exception: only tissue from first surgery is allowed for Cohort 16.
• •Available MRI/CT scans from primary brain tumour at initial diagnosis
• •Patient's consent
• •Deceased patient:
• •The clinical data and/or biological material and/or CT/MRI/PET images can be accessed and used if at least one of the following three conditions is met:
• •The patient agreed beforehand in his/her lifetime to a further use of his/her data and/or biological material and/or CT/MRI/PET images, or,
• •There is consent of a relative to use data and/or biological material and/or CT/MRI/PET images of the deceased patient, or,
• •There is a reference to a corresponding legal declaration covering the exemption in case of the impossibility or disproportion of getting access to an informed consent (e.g., causing strain on relatives of deceased patients).
• •Additionally, in all cases the following three points need to be fulfilled:
• •No documentation of previous objection of the patient to the (re-)use of their data, biological material, CT/MR/PET images for research purposes
• •A notification to an ethics committee for the re-use of these data, biological material and CT/MRI/PET images
• •Any other national requirements are fulfilled, if applicable