Loading clinical trials...

Impact of Chest Wall Mechanics on Lung and Cardiovascular Function During Delayed Sternal Closure | Clinical Trials | Clareo Health

COMPLETEDNA

Impact of Chest Wall Mechanics on Lung and Cardiovascular Function During Delayed Sternal Closure

NCT05257525•The Hospital for Sick Children

View on ClinicalTrials.gov

Summary

This study aims to describe chest wall mechanics during delayed sternal closure (DSC) in neonates following cardiopulmonary bypass or palliation of congenital heart diseases.

Detailed Description

This research study is being done so that investigators can understand the complex interactions between the heart, the lungs and the chest wall after heart surgery. Understanding this may guide future care that can help patients with their recovery from heart surgery. The heart and lungs work together to make sure the body has the oxygen-rich blood it needs to function properly. The chest wall protects the heart, lungs, and other important organs. Investigators would like to learn how a patient's chest wall contributes to the heart and lungs interaction when the chest is left open after heart surgery. Investigators will be using a device called an esophageal pressure catheter to estimate the pressure that is transmitted to the lungs and heart, called pleural pressure. Previous research has shown that this pressure measurement is used to adjust the breathing machine for patients with lung diseases. Measuring the pressure transmitted to the lungs and heart after heart surgery and delayed chest wall closure may help investigators understand how the chest wall contributes to the heart and lung interaction.

Eligibility

Age

0 - 0 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. Informed consent provided by parent or primary guardian.
•2. Aged \<28 days of life at the time of cardiac surgery.
•3. Undergone surgery using CPB for congenital heart disease.
•4. Undergoing DSC in CCCU.

Exclusion Criteria

•1. Gestational age \< 37 weeks or weight \< 2 kg at the time of surgery.
•2. Endotracheal tube leak \>20%.
•3. Need of extracorporeal support (ECMO), inhaled nitric oxide.
•4. Pre-existing pulmonary disease (For example: Congenital diaphragmatic hernia).
•5. Pre-existing or new arrhythmia that can impact hemodynamic assessment.
•6. Severe coagulopathy or any other contraindication for the insertion of a nasogastric catheter (e.g., history of tracheo-esophageal fistula).

Locations (1)

The Hospital for Sick Children

Toronto, Ontario, Canada

Key Dates

Start Date

August 26, 2022

Primary Completion Date

October 26, 2023

Completion Date

January 8, 2024

Last Updated

July 16, 2025

Enrollment

ACTUAL participants

Conditions

Palliation of Congenital Heart DiseasesCardiopulmonary BypassChest Wall MechanicsNeonatal Delayed Sternal Closure

Interventions

Esophageal manometry catheter at various PEEP levels and tidal volumes

OTHER

Ultrasound Guided Bilateral Pectoral Nerve Block Versus Bilateral Transverse Thoracic Plane Block In Pediatric Patients Undergoing Corrective Cardiac Surgeries Requiring Cardiopulmonary Bypass Via Median Sternotomy

NCT06984276

UltrasoundPectoral Nerve Block+5 more

View study

RECRUITINGNA

Effect of Low Tidal Volume Ventilation on Postoperative Delirium

NCT06752421

Postoperative Delirium (POD)Cardiopulmonary Bypass+2 more

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: July 16, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Impact of Chest Wall Mechanics on Lung and Cardiovascular Function During Delayed Sternal Closure

Inclusion Criteria

Exclusion Criteria

Ultrasound Guided Bilateral Pectoral Nerve Block Versus Bilateral Transverse Thoracic Plane Block In Pediatric Patients Undergoing Corrective Cardiac Surgeries Requiring Cardiopulmonary Bypass Via Median Sternotomy

Effect of Low Tidal Volume Ventilation on Postoperative Delirium

Amobarbital and Cardiopulmonary Bypass

Optimal Cardiopulmonary Bypass and Anticoagulation Management Strategies in Obese Patients Undergoing Cardiac Surgery

Protective Effect of Probacine Against Negative Gut Metabolism and Organ Dysfunction After Cardiovascular Surgery (PANDA IV)

Influence of Lung Volume Optimization Maneuver in Ventilated Children on Cardiac Output and Lung Compliance in Children With Congenital Heart Disease Undergoing Surgical Repair