Age

18–80

Sex

ALL

Healthy volunteers

Not accepted

Patients referred to EUS with FNB for suspected pancreatic cancer unresectable or metastatic based on imaging findings
Availability of biopsies obtained during EUS-FNB
Histological diagnosis of pancreatic ductal adenocarcinoma of any stage
Patients must be fit for chemotherapy administration
They have to express their willingness to be followed up at our pancreatic high volume centers
Age \>18 and \<80 years
Able to sign informed consent

Genetic, Microenvironmental, and Immunological Factors in Unresectable Pancreatic Ductal Adenocarcinoma