Efficacy of Neoadjuvant Hyperthermic Intraperitoneal Chemotherapy in Advanced High-grade Serous Ovarian Cancer (the NHIPEC Trial)

Inclusion Criteria

• •1. International Federation of Gynecology and Obstetrics(FIGO) stage IIIC-IVA, HGSOC
• •2. Patients with Fagotti score ≥8
• •3. Adequate kidney function (blood creatinine 58-96 µmol/L)
• •4. Adequate haematological function (haemoglobin ≥110g/L, leucocytes ≥4.0×109/L, neutrophils ≥2.0×109/L, platelets≥100×109/L)
• •5. Adequate liver function (serum total bilirubin 3.4-22.2µmol/L, alanine aminotransferase (ALT) 7-40U/L, aspartate aminotransferase (AST) 13-35U/L, AST/ALT ≤1.5)
• •6. World Health Organization(WHO) score 0-2