Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Seagen Inc.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
HIV-1 seropositive with documentation of infection
Immunological nonresponder, defined as:
* Has been on ART with an HIV viral load \<50 copies/mL for at least 24 months
* Has a CD4+ T-cell lymphocyte count between 51 to 200 cells/µL
Life expectancy of \>9 months.
Participant is negative for hepatitis B, or if infected with hepatitis B, receiving anti-hepatitis B therapy
You may not be if
Any currently active AIDS-defining illness per Category C conditions according to the CDC Classification System for HIV Infection, with the following exceptions:
* Limited cutaneous Kaposi's sarcoma not currently requiring systemic therapy
* Wasting syndrome due to HIV or any other AIDS-defining illness for which no therapeutic treatment is required OR the required treatment is not included in the list of prohibited medications
Acute liver disease or any other active infection secondary to HIV requiring acute therapy
History of progressive multifocal leukoencephalopathy (PML)
Prior clinical John Cunningham virus (JCV) infection, history of JCV identified in cerebrospinal fluid, or presence of JCV antibodies at screening
Cirrhosis secondary to any cause
Any immunomodulating therapy (excluding premedication steroid) within 4 weeks prior to the screening visit
Prior malignancy within 2 years other than cutaneous basal cell or squamous cell carcinoma, carcinoma in situ of the cervix, anal intraepithelial neoplasia, or cutaneous Kaposi's sarcoma
