Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Milton S. Hershey Medical Center
With
National Heart, Lung, and Blood Institute (NHLBI)
Smokers with COPD have a higher pack-year history and nicotine dependence compared to regular smokers as exemplified by the relatively large proportion of patients diagnosed with COPD that continue to smoke (95%).
This is a translational project which addresses the changing profile of tobacco product use in the United States (US) and the need for data regarding toxicity pathways for new nicotine products such as EC. In particular it focuses on critical scientific and clinically relevant gaps relating to oxidants in EC and their potential long-term cardiopulmonary effects. The study will obtain new information regarding the potential cardiopulmonary toxicity resulting from exposure to EC-derived oxidants that may lead to long-term disease development.
Age
21–74
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Mild to moderate COPD
Smokes a popular brand of cigarette
Willing to use an e-cigarette to reduce cigarette smoking down to 75% of their daily baseline cigarette use
Ability to read, write and understand English
Ability to provide informed consent and attend study visits
You may not be if
History of active, chronic drug abuse or alcohol abuse problems
Actively changing smoking behavior
Unwilling or unable to provide blood samples
Pregnant, planning to become pregnant, or nursing
Use of tobacco products other than cigarettes in the past 30 days
Recent history (\< 6 months) of myocardial infarction (MI)
Any unstable or life threatening cardiac arrhythmia or cardiac arrhythmia requiring intervention or drug therapy within the past year. Antiarrhythmic drugs include amiodarone, flecainide, IV ibutilide, IV lidocaine, procainamide, propafenone, quinidine, tocainide
Hospitalization for heart failure (NY Heart Association III or IV) within the past year
Uncontrolled hypertension
Known allergy to vegetable glycerin and propylene glycol
History of seizures or medications to prevent seizures
Clareo Health | Electronic Cigarette-derived Oxidants and Cardiopulmonary Effects
