A Randomized Trial of NSAID Dosing Strategies

Exclusion Criteria

• •Contraindication to NSAIDs (allergy to NSAID or allergy to aspirin without history of tolerating NSAIDs, history of gastrointestinal bleeding, daily medication for gastritis or PUD, chronic kidney disease 2-5, heart failure)
• •Contraindication to acetaminophen (hepatitis or cirrhosis)
• •Use of an NSAID within the previous eight hours
• •Use of acetaminophen within the previous eight hours
• •Chronic pain, defined as any pain on \>50% of days for at least 3 months prior to onset of acute pain
• •Recurrent pain in the same body part as the presenting complaint