DSM-5 diagnostic criteria for MDD, Generalized Anxiety Disorder, Social Phobia, Panic Disorder, Post Traumatic Stress (diagnosed using the SCID-5)
Written informed consent
For MDD subjects, a baseline Hamilton Depression Rating Scale score \> 16 (17-item version)
Right-handed
Has a smartphone (iPhone or Android) (needed for Ecological Momentary Assessment)
Absence of any psychotropic medications for at least 2 weeks (6 weeks for fluoxetine, 6 months for neuroleptics, 2 weeks for benzodiazepines, 2 weeks for any other antidepressants)
Absence of medical, neurological, and psychiatric illness (including alcohol and substance abuse), as assessed by subject history and a structured clinical interview (diagnosed using the SCID-5)
Written informed consent
Right-handed
Absence of any medications for at least 3 weeks
Has a smartphone (iPhone or Android) (needed for Ecological Momentary Assessment)
You may not be if
Subjects with suicidal ideation where outpatient treatment is determined unsafe by the study clinician
Pregnant women or women of childbearing potential who are not using a medically accepted means of contraception
Serious or unstable medical illness, including cardiovascular, hepatic, renal, respiratory, endocrine, neurologic or hematologic disease
History of seizure disorder
History or current diagnosis of any of the following DSM-IV psychiatric illnesses: organic mental disorder, schizophrenia, schizoaffective disorder, delusional disorder, psychotic disorders not otherwise specified, bipolar disorder, obsessive-compulsive disorder, patients with mood congruent or mood incongruent psychotic features, substance dependence, substance abuse within the last 12 months (with the exception of cocaine or stimulant abuse; which will lead to exclusion)
History of cocaine or stimulant use (e.g., amphetamine, cocaine, methamphetamine)
History of use of dopaminergic drugs (including methylphenidate)
History or current diagnosis of dementia
Patients with mood congruent or mood incongruent psychotic features
Current use of other psychotropic drugs
Clinical or laboratory evidence of hypothyroidism
Patients with a lifetime history of electroconvulsive therapy
Failure to meet standard magnetic resonance imaging safety requirements
Abnormal ECG and lab results
History of seizure disorder or currently on anticonvulsants
