Safety and Feasibility of Argatroban As Anticoagulant in Adults with ECMO

Exclusion Criteria

• •History of Heparin-induced thrombocytopenia (HIT)
• •High risk of bleeding, contraindication for anticoagulation (eg. active GI-bleeding, Intracerebral bleeding; Platelet count \<50G/l, congenital bleeding disorder)
• •Pregnancy
• •Severe Liver disease (SOFA score liver domain 4 points = Bilirubin \>12mg/dl)
• •Postoperative admission
• •Strong lupus anticoagulant or acquired intrinsic clotting factor deficiency at admission (APTT \>50 sec without anticoagulation).