Treatment of Eosinophilic Chronic Rhinosinusitis Utilizing Betamethasone Dipropionate Nasal Cream

Exclusion Criteria

• •Subjects with known hypersensitivity or contraindications to Betamethasone Dipropionate, corticosteroids or topical anaesthesia.
• •Subjects with sino-nasal abnormalities, disease or implanted devices that prevent application of the therapy.
• •Previous enrolment in this study.
• •Subjects currently required systemic corticosteroid use or receiving biologic therapy as part of their disease management plan or who meet the PBS criteria for severe lower airway disease.
• •Subjects with history or current glaucoma or cataract or if they have abnormal IOP at screening or pre-treatment (abnormal IOP is defined as greater than 21 mm Hg).
• •Subjects with other conditions that could lead to elevated eosinophils such as Hypereosinophilic Syndromes, including Churg-Strauss Syndrome, or Eosinophilic Esophagitis.
• •Subjects with acute sinusitis.
• •Subjects with known immunodeficiency.
• •Subjects with Diabetes (Type 1).
• •Subjects with cystic fibrosis.
• •Pregnant subjects or subjects currently lactating as the effect on human pregnancy is unknown.