Prevention of Postoperative Hypocalcemia of Oral Vitamin D Supplementation Before Total Thyroidectomy

Exclusion Criteria

• •Patients with confirmed hypocalcemia or hypercalcemia before surgery
• •Patients receiving calcium or vitamin D treatment before surgery, patients with excessive vitamin D
• •Patients with a previous history of parathyroid disease or a history of cervical irradiation
• •Patients with confirmed parathyroid comorbidity
• •Patients with diseases or conditions that cause hypercalcemia or hypercalciuria (myeloma, bone metastases, or other malignant bone diseases)
• •Patients with confirmed renal dysfunction (glomerular filtration rate \<60mL/min/1.73m2) before surgery or with a history of chronic renal failure
• •Renal stone disease patient, kidney stone disease patient
• •Patients with bowel disease that may affect serum vitamin D levels (celiac disease, small intestine resorption disease, small bowel resection history)
• •Patients taking drugs that may affect serum calcium or vitamin D levels (anticonvulsants, bisphosphonates, cisplatin, aminoglycosides, diuretics, proton pump inhibitors, glucocorticoid benzodiazepine derivatives, etc.)
• •Uncontrolled hypertension, diabetes, and clotting disorders
• •Cardiovascular disease (angina pectoris, heart failure, myocardial infarction, coronary artery disease, history of arrhythmia treatment, stroke, transient ischemic attack), and taking medications for arrhythmia
• •Drug Abuse and Alcohol Abuse
• •Patients who participated in other drug clinical trials within 30 days
• •Patients with a history of allergies to drugs
• •For women, pregnant and lactating patients
• •Patients judged unsuitable by the person in charge of the clinical trial
• •Patients with genetic problems such as galactose intolerance, lactose deficiency, or glucose-galactose malabsorption disorder