World Trade Center Particulate Matter Induced Cardiorespiratory and Vascular Dysfunction: a MultiOmic Approach (CaRVD)

Inclusion Criteria

• •1. Age 21-90
• •2. FDNY rescue and recovery worker
• •3. Documented WTC exposure
• •4. Consented/Enrolled member of the WTC-HP
• •5. Subjects are willing and able to consent for themselves to study enrollment
• •6. Subjects are willing and able to participate in study procedures
• •7. Are able to perform their activities of daily living independently
• •8. Are either light duty or retired FDNY Firefighters
• •9. Spirometry available within the last 24 months, and at a post-9/11 visit.
• •10. Have means to accommodate transportation to/from in-person visit Are able to attend a single visit at the CTSI (462 1st Avenue, C \& D 4th Floor)
• •11. Pre-9/11 spirometry with FEV1%predicted ≥LLN and if not available 1st -post 9/11 spirometry with an FEV1 \>80% predicted.
• •12. No recorded positive AHR testing prior to 9/11
• •13. Exposure at the WTC-site within 2 weeks of 9/11/2001
• •14. Entered WTC-HP before the site closure on 7/24/2002
• •15. Serum from their first post 9/11 WTC-HP visit is available in the biorepository and may be assayed
• •16. Are not currently being treated for malignancy
• •17. Subjects will either need to be defined as having WTC-AHR or be designated controls