Lead Sponsor

University of Michigan

Collaborators

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•1. Age over 18.
•2. Participant must be able to understand and provide informed consent
•3. No evidence of infectious illness (defined as fever \>38⁰C, vomiting, diarrhea, new cough, new shortness of breath, new congestion, new runny nose, new headache or sore throat) within 14 days of vaccine administration.
•4. Subjects must have a history of adverse reaction to either the Pfizer-BioNTech mRNA COVID vaccination or the Moderna mRNA COVID vaccination, a personal history of allergic reaction without prior mRNA COVID vaccination, or a history of adverse reaction to natural COVID infection.
•5. Females of childbearing potential must have a negative pregnancy test prior to vaccination.

•1. Under age 18
•2. Inability or unwillingness of a participant to give written informed consent
•3. Evidence of COVID-19 infection within 21 days of vaccination visit
•4. History of antibody agent or convalescent plasma for treatment or prevention of COVID-19 within 90 days
•5. Individuals with known history of a severe allergic reaction (e.g., anaphylaxis) to any component of the Pfizer-BioNTech mRNA COVID-19 vaccination or the Moderna mRNA COVID-19 vaccination.
•6. History of underlying immune disorder.
•* Pregnancy
•* Immunocompromised
•* Persons with primary or acquired immunodeficiency
•* Persons on anti-rejection therapy following solid organ transplant or bone marrow transplant
•* Persons on biologic therapeutic agents
•* Persons with malignancy and ongoing or recent chemotherapy
•* Persons receiving systemic immunosuppressive therapy, including corticosteroids equivalent to 20 mg/day of prednisone for 2 weeks
•* Persons with chronic kidney disease stage 3 or higher
•* Persons with history of significant pulmonary compromise

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