Effects of CROCUVIS+® on Computer Vision Syndrome, Sleep and Mood Disorders

Exclusion Criteria

• •Monocular corrected distance visual acuity \>0.0 LogMAR.
• •Ocular pathology under treatment at the time of the study.
• •Previous ocular surgery that could affect the tear film or the ocular surface.
• •Ocular Surface Disease Index (OSDI) questionnaire score ≥13.
• •Previous diagnosis or history of dry eye syndrome and/or blepharitis.
• •Regular (daily) use of rigid or soft contact lenses ≥3 days a week.
• •Regular use of any ocular lubricant.
• •History of oral intake of dietary supplements, with or without herbal ingredients, intended to contribute, maintain or reduce the risk of suffering diseases related to visual function, mood or sleep within the four weeks before the study enrollment.
• •Systemic disease:
• •1. Uncontrolled hypertension (systolic/diastolic blood pressure \>140/90 mmHg).
• •2. Uncontrolled diabetes mellitus (fasting blood glucose level \>180 mg/dL).
• •3. Rheumatoid arthritis.
• •4. Tumor disease.
• •5. Active hepatitis (type B and C).
• •6. Active infectious disease.
• •7. Kidney disease that compromises diuresis.
• •Current systemic treatment or in the last 3 months with drugs that may interfere with the results, for example:
• •1. Opioids.
• •2. Antipsychotics.
• •3. Antibiotics (tetracyclines, sulfonamides)
• •4. Antiarthritic drugs (hydroxychloroquine)
• •5. Hypotensive drugs (beta-blockers)
• •6. Anticoagulants (heparin, warfarin, or clopidogrel)
• •7. Antidepressants (such as fluoxetine, among others)
• •8. Hypnotics (eg, benzodiazepines)
• •Habitual smoker and/or alcohol drinker. More than 3 cigarettes per day and/or more than 3 Standard Drink Units (SDU) per week, including weekends. SDU is defined as the consumption of 10 ml of alcohol.
• •Regular job with rotating shifts including night shift in the last month (including weekends).
• •Pregnancy or breastfeeding (also excludes recent pregnancy within the last 3 months) and women planning to become pregnant.
• •Participation in another clinical trial in the last 3 months.
• •Take any type of dietary supplements with botanical components in the last month.