Safety and Efficacy of Remote Ischemic Conditioning on Cerebral Amyloid Angiopathy. (RIC-CAA)

Exclusion Criteria

• •1. Familial hereditary CAA or other hereditary small-vessel disorders.
• •2. Previous intracranial hemorrhage caused by other reasons, such as tumor, cerebral cavernous angioma, ruptured aneurysm, arteriovenous malformation, venous sinus thrombosis and so on.
• •3. A history of stroke within 3 months.
• •4. The degree of intracranial or extracranial large artery stenosis \>50%.
• •5. Clinical diagnosis of probable AD by National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria.
• •6. Significant cognitive impairment (defined as Mini-mental State Examination (MMSE) score of ≥20 (primary school) or ≥24 (junior school or above) or other diseases resulting from severe cognitive impairment.
• •7. Inability to walk 6m unaided or other conditions that affected gait performance, such as Parkinson.
• •8. Illiteracy and patients with severe visual or hearing impairment.
• •9. Contraindication to MRI scan, such as intracranial metal implants, cardiac pacemaker, severe claustrophobia, history of seizures and so on.
• •10. Patients with missing or poor-quality MRI sequences at baseline and follow-up.
• •11. Patients with a pre-existing neurological deficits (modified Ranks scale score \>2) or psychiatric disease that would confound the neurological or functional evaluations.
• •12. Alcohol dependence and other psychoactive substance abuse
• •13. Contraindication for remote ischemic conditioning: severe soft tissue injury, limb deformities, fracture, atrial fibrillation or peripheral vascular disease in the upper limbs.
• •14. Life expectancy of less than 1 year due to co-morbid conditions.
• •15. Severe, sustained hypertension (SBP \> 180 mmHg or DBP \> 110 mmHg).
• •16. Severe renal or hepatic disease.
• •17. Known pregnancy (or positive pregnancy test), or breast-feeding.
• •18. Concurrent participation in another research protocol for investigation of another experimental therapy.
• •19. Any condition which, in the judgment of the investigator, might increase the risk to the patient.