Finding studies
Finding studies
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Ching-Wei Tzeng, MD
CONTACT
Lead
M.D. Anderson Cancer Center
With
Primary Objective: To examine the safety and feasibility of Y-90 TARE directed to the right hemi-liver for induction of left liver FLR hypertrophy as part of a planned hepatectomy for patients with CLM. Secondary Objectives: * To describe changes in liver volume after Y-90 TARE, including: * The kinetic growth rate (KGR) of the FLR * Degree of hypertrophy 6 weeks after TARE * Atrophy of targeted right hemi-liver from TARE date to date of surgery * To describe additional interventional procedures needed to induce additional hypertrophy if insufficient hypertrophy from Y-90 TARE * To assess the proportion of TARE patients who undergo attempted and complete curative-intent resection of CLM * To assess measures of disease control, including: * Tumor marker trend * RECIST/mRECIST criteria * CT morphologic response * PET CT response * To describe Patient Reported Outcomes using MDASI-GI * To assess FLR liver quality, right-sided surgical adhesions from TARE intraoperatively * To describe dosimetry of individual liver lesions - using SPECT/CT, CT, and pathology correlation * To describe change in liver function measured by the pre- and post-TARE HIDA SPECT/CT scans and hepatic function blood tests
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
