Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Ohio State University Comprehensive Cancer Center
Randomized controlled trial (RCT) where obese participants (N=133) are randomized to 2 arms: \[i\] IMT 4 wks + Exercise 12 wks, \[ii\] SHAM 4 wks + Exercise 12 wks).
Age
18–any
Sex
FEMALE
Healthy volunteers
Not accepted
You may be eligible if
completed active treatment for a Stage 0-III breast cancer diagnosis within 6 months to 5 years of enrollment.
obese as defined by a body mass index (BMI) of 30 to 50 kg/m2
patients who are on adjuvant endocrine therapy will be allowed to participate.
sedentary (participating in less than 90 min of moderate intensity activity per week) and have at least one limitation in activity on the 10-question RAND-36 Physical Function Subscale to ensure some exercise intolerance
You may not be if
functional limitations that make independent exercise unsafe
metastatic breast cancer
ongoing or active infection with recent antibiotics or steroids
Bilateral Axillary lymph node dissection (ALND) of \>5 lymph nodes on each side, which could increase risk of lymphadenopathy with repeated blood pressure measurements during exercise or if patient has been advised by their clinician to avoid repeated BP measures on both arms. Bilateral Sentinel Lymph Node Biopsy (SLNB) will be allowed.
psychiatric illness/social situations that would limit compliance with study requirements
orthopedic or neuromuscular disorders or arthritis that preclude participation in exercise
unwilling or unable to follow protocol requirements
pregnant or nursing
any condition which in the investigator's opinion deems the subject an unsuitable candidate to participate in this study
presence of provokable ECG changes suggestive of heart disease, or dangerous arrhythmias or exercise induced hypertension, etc. during the cardiopulmonary exercise test
