CAV Regimen Bridging to HSCT for R/R AL

Inclusion Criteria

• •1. Patients with AL must meet one of the following criteria ：A or B. A: relapsed AL disease was defined as follows: (1) Reappearance of leukemic blasts in the peripheral blood after CR; or (2) detection of \>5% blasts in the bone marrow (BM) not attributable to another cause(e.g. regeneration after consolidation therapy); or (3) extramedullary relapse.
• •B: refractory AL disease was defined as follows: (1) failure to achieve CR, CRh or CRi after two courses of intensive induction treatment. or (2) failure to achieve complete remission after one cycle of induction chemotherapy or a reduction in the number of blasts of less than 50% after one cycle of induction treatment, with residual blasts \>15%.
• •2. patients without ≥grade 3 of cardiac, hepatic, pulmonary, or renal dysfunctions.
• •3. sign informed consent voluntarily.
• •4. Patients aged between 16 and 70 years old, male or female is permitted.
• •5. ECOG performance status score less than 1.
• •6. The expected survival is longer than 3 months.