1. Diagnosed as mCRPC according to EAU-ESTRO-SIOG 2016 and PSA \> 10ng/ml;
2. No previous treatment with novel hormonal therapy;
3. ECOG 0-2;
4. Normal organ function, WBC \>= 3000/mm3 or Neutrophil \>= 1500/mm3;
5. Aged 18 to 85 years old when issuing written informed consent;
6. Life expectancy \> 12 months.
7. Consent and able to carry out follow-up visit and cooperate with all other study procedures.
You may not be if
1. Severe disease or other medical conditions suggesting a high risk of death within 1 year, which may interfere with follow-up. Decided by investigator;
2. Diagnosed with any other malignant tumor within 3 years before enrollment;
3. Unable to provide necessary follow-up information;
4. Other conditions that are judged as ineligible by the investigator.
