Study to Evaluate the Efficacy, Safety, and Tolerability of Luvadaxistat in Participants With Cognitive Impairment Associated With Schizophrenia

Exclusion Criteria

• •Participants will be excluded from the study if they meet any of the following criteria:
• •1. Pregnant or breastfeeding or plans to become pregnant during the study.
• •2. Exhibit more than a minimal level of extrapyramidal signs/symptoms.
• •3. Schizophrenia diagnosis occurred before 12 years of age.
• •4. Lifetime diagnosis of schizoaffective disorder, bipolar disorder, or obsessive-compulsive disorder.
• •5. Recent occurrence of panic disorder, depressive episode, or other comorbid psychiatric conditions.
• •6. Considered by the investigator to be at imminent risk of suicide or injury to self, others, or property, or the participant has attempted suicide within 6 months before screening.
• •7. Diagnosis of moderate or severe substance use disorder (with the exception of nicotine dependence) within 12 months prior to screening.
• •8. Positive drug screen for disallowed substances.
• •9. Any other medical or psychiatric condition or cognitive impairment that may interfere with study conduct or clinical assessments.