Novel MRE Technique to Assess a Risk Factor for Liver Cancer

Exclusion Criteria

• •1. Presence of any other form of liver disease, including viral hepatitis, autoimmune hepatitis, alcoholic liver disease, genetic causes of chronic liver disease, cardiogenic liver disease, and HIV positivity (can cause liver fibrosis).
• •2. ALT\>300 U/l
• •3. Total serum bilirubin ≥ to 1.3 mg/dL (Gilbert's Syndrome patients are excepted)
• •4. International Normalized Ratio (INR) ≥ 1.3
• •5. MELD\>9
• •6. Serum creatinine \>2.0mg/dl
• •7. Known alcohol abuse or alcohol use disorder (AUDIT profile and/or pos. urine ethylglucuronide):
• •* \>20 g/day for women
• •* \>30 g/day for men
• •8. Active substance abuse
• •9. Platelet count ≤100//mm3
• •10. Hemoglobin \<11 g/dl in females or \<12 g/dl in males
• •11. Presence/history of HCC, or other primary or metastatic cancer to the liver.
• •12. History of liver transplantation
• •13. History of bariatric surgery
• •14. History of inflammatory bowel disease
• •15. History of advanced pulmonary disease
• •16. Any concerns regarding compliance by enrolling physician
• •17. Pregnant or lactating women.
• •18. Presence of cardiac implantable electronic device (CIED)
• •19. History of CIED with retained leads
• •20. Presence of any metallic foreign body that is unsafe for the MRI environment
• •21. Inability to undergo MRI based on responses to the MRI screening form
• •22. History of claustrophobia or the need for sedation to undergo MRI