DEP Combine With PD-1 Antibody as an Treatment for EBV-HLH

Inclusion Criteria

• •1. Meet hemophagocytic lymphohistiocytosis (HLH)-04 diagnostic criteria; EBV-DNA in peripheral blood or EBER in tissue were positive, patients were diagnosed with EBV associated HLH (EBV-HLH).
• •2. . The expected survival time is more than 1 month.
• •3. Age \>18 years old, gender is not limited.
• •4. Serum creatinine ≤ 1.5 times normal；
• •5. Serum human immunodeficiency virus(HIV) antigen or antibody negative； Hepatitis C virus (HCV) antibody is negative, or HCV antibody is positive, but HCV RNA is negative；HBV copies less than 1E+03 copies/ml.
• •6. No thyroid dysfunction. The left ventricular ejection fraction (LVEF) was normal.
• •7. No uncontrollable infection.
• •8. Contraception for both male or female.
• •8\. Informed consent obtained.