Accuracy of Dexcom G6® and FreeStyle Libre® Sensors in Standardized Hypoxemia Conditions

You may be eligible if

• No history of respiratory diseases (childhood asthma, respiratory allergies, exercise-induced asthma or dyspnea)
• Willing to participate and able to sign an informed consent form (ICF)
• Being affiliated with the French Social Security
• type 1 diabetes mellitus or type 2 diabetes mellitus (ADA definition)
• Age : 18 to 75 years
• stable diabetes treatment for more than 3 months
• no diabetic retinopathy
• no diabetic neuropathy
• no cardiovascular diseases
• no contra-indication for coronary computed tomography angiography or myocardial perfusion scintigraphy.
• Age : 18 ; 40 years
• No diabetes
• No persistant drug use \> 3 months except contraception
• Body mass index : \[18,5 - 29,9\] kg/m2
• Active smokers
• Pregnant or breastfeeding women, women of childbearing age without effective contraception
• Known allergies to the patch.
• Skin lesions at the sensor site that may interfere with sensor placement or accuracy
• Major cardiovascular complications within the past 3 months
• Decompensated congestive heart failure
• Chronic respiratory failure
• Chronic renal failure
• Resting ambient air O2 saturation ≤95%.
• Treatment with systemic corticosteroids
• Severe hypertension (≥180 mmHg systolic pressure or ≥ 100 mmHg diastolic pressure)
• Any concomitant disease or condition that the investigator believes may compromise patient safety or affect the conduct of the study
• Anemia (Hb\<12g/dl)
• History of severe mountain sickness
• Concurrent participation in another clinical research study,
• Persons benefiting from enhanced protection
• Absolute contraindications to physical activity (HAS definitin) :
• Pulmonary arterial hypertension (\> 60 mm Hg)
• Presence of intra-cardiac thrombus
• Acute pericardial effusion
• Severe obstructive cardiomyopathy
• Symptomatic aortic stenosis
• Recent thrombophlebitis with or without pulmonary embolism