EndoArt® Implantation in Subjects With Chronic Corneal Edema

Exclusion Criteria

• •Individuals for participation will be ineligible for the study if any of the following conditions apply:
• •1. History of ocular Herpetic keratitis.
• •2. Scarred cornea resulting in visual impairment with intact endothelium (cell density ≥ 1500).
• •3. History of posterior vitrectomy.
• •4. Post PKP
• •5. Have an irregular posterior cornea (e.g., post trauma).
• •6. Have a current infection of the cornea.
• •7. Have band keratopathy and/or limbal stem cell deficiency.
• •8. Have clinically severe dry eye disease which needs more than 4 drops of lubricant per day.
• •9. Phthisis bulbi or subject is at risk of developing phthisis.
• •10. Subject with medically uncontrolled high intra ocular pressure.
• •11. Aphakia.
• •12. Anterior chamber IOL or fixated anterior chamber IOL.
• •13. Pseudophakodonesis.
• •14. Have large iris defect which could compromise intraoperative air bubble formation
• •15. Have undergone corneal refractive surgery.
• •16. History of neurotrophic cornea.
• •17. History of recurrent corneal erosion or persistent epithelial defect.
• •18. IridoCorneal Endothelial (ICE) Syndrome or any rare disease/ syndrome creating anatomical or physiological anomalies of the anterior chamber (e.g., corectopia).
• •19. Recurrent posterior, intermediate or anterior uveitis.
• •20. Subject receiving regular intravitreal injection
• •21. Currently participating or have participated in an investigational study, other than this study, within the past 60 days.