The REVEALPLAQUE Study: A pRospEctiVe, multicEnter Study to AnaLyze PLAQUE Using CCTA

Exclusion Criteria

• •1. 1\. CCTA showing no stenosis
• •2. Uninterpretable CCTA by HeartFlow assessment, in which image quality prevents FFRCT from being processed.
• •3. Acute chest pain
• •4. CABG (coronary artery bypass graft) prior to CCTA acquisition
• •5. Prior history of PCI for 3 or more vessels
• •6. MI (myocardial infarction) less than 30 days prior to CCTA or between CCTA and ICA.
• •7. Suspicion of acute coronary syndrome (acute myocardial infarction or unstable angina)
• •8. Known complex congenital heart disease
• •9. Tachycardia or significant arrhythmia
• •10. Subject requires an emergent procedure
• •11. Evidence of ongoing or active clinical instability, including acute chest pain (sudden onset), cardiogenic shock, unstable blood pressure with systolic blood pressure \<90 mmHg, and severe congestive heart failure (NYHA \[New York Heart Association\] III or IV) or acute pulmonary edema
• •12. Any active, serious, life-threatening disease with a life expectancy of less than 2 months
• •13. Currently enrolled in another study utilizing FFRCT or in an investigational trial that involves a non-approved cardiac drug or device
• •14. Persons under the protection of justice, guardianship, or curatorship