Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
CinCor Pharma, Inc.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Is on a stable regimen of background antihypertensive agent(s) for at least 8 weeks and would be considered a candidate for an additional antihypertensive agent at the time of screening ;
Has a mean seated systolic blood pressure (SBP) ≥ 140 mmHg or ≥ 130 mmHg if diabetic;
Demonstrates ability to be adherent to the study drug and their anti-hypertensive medication during a run-in period
If taking an SGLT2 inhibitor, the regimen must be stable for at least 8 weeks prior to randomization; and
Agrees to comply with the contraception and reproduction restrictions of the study;
You may not be if
Has a mean seated systolic blood pressure (SBP) ≥180 mmHG;
Has a body mass index (BMI) \>50 kg/m2;
Is using alpha or beta blockers for any primary indication other than systemic hypertension (eg, migraine headache);
Is not willing or not able to discontinue an MRA or potassium sparing diuretic as part of an existing antihypertensive regimen;
Has documented estimated eGFR \<30 mL/min/1.73m2;
Has known and documented New York Heart Association stage III or IV chronic heart failure;
Has had a stroke, transient ischemic attack, hypertensive encephalopathy, acute coronary syndrome, or hospitalization for heart failure within 6 months before screening;
Major cardiac surgery within 6 months before Screening;
Has chronic permanent atrial fibrillation;
Has uncontrolled diabetes with glycated hemoglobin \>10% at Screening;
Has planned dialysis or kidney transplantation planned during the course of the study;
Prior solid organ transplant and/or cell transplants;
Sodium \<130 mEq/L;
Potassium \<3.5 mEq/L;
Potassium \>5 mEq/L;
White blood cell count \>15 × E9/L or absolute neutrophil count \<1 × E9/L at Screening;
Is positive for HIV antibody, hepatitis C virus RNA, or hepatitis B surface antigen;
Has typical consumption of ≥14 alcoholic drinks weekly;
