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Gas Exchange Derangement Physiopathology in Critically Ill Patients With COVID-19

Gas Exchange Derangement Physiopathology and Response to Different Levels of Positive End-expiratory Pressure in Critically Ill Patients With COVID-19

NCT05132933•Policlinico Hospital

View on ClinicalTrials.gov

Summary

The study was designed to understand the pathophysiology of gas exchange derangement in critically ill patients with COVID-19. Specifically we will evaluate the effect of 3 different levels of positive end-expiratory pressure (PEEP) and two different levels of inspiratory oxygen fraction (FiO2) on gas exchange by analyzing shunt and dead space. Furthermore, complete respiratory mechanics and distribution of ventilation and perfusion by electrical impedance tomography will be assessed at each level of PEEP.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Patients admitted in intensive care unit for COVID-19 related Acute Respiratory Distress Syndrome (ARDS) requiring invasive mechanical ventilation

Exclusion Criteria

•Pregnancy
•Hemodynamic instability (80-90 mmHg increase or 30-40 mmHg decrease systolic arterial pressure compared to baseline value or need of vasopressors to maintain systolic blood pressure higher than 85 mmHg or electrocardiogram evidence of ischemia/arrhythmias)
•Presence of pneumothorax and/or pneumomediastinum
•Contraindications to Electrical Impedance Tomography (pacemaker, implantable cardioverter defibrillator, thoracic drainages)

Locations (1)

Ospedale Maggiore Policlinico

Milan, MI, Italy

Key Dates

Start Date

October 1, 2021

Primary Completion Date

June 30, 2022

Completion Date

December 30, 2022

Last Updated

January 25, 2024

Enrollment

ACTUAL participants

Conditions

Respiratory Failure

Interventions

PEEP trial - Electrical Impedance Tomography

PROCEDURE

Driving Pressure During Surgeries With High Risk for Postoperative Pulmonary Complications

NCT07186933

Postoperative Pulmonary AtelectasisPostoperative Pulmonary Complications+8 more

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RECRUITINGNA

Non-Invasive Ventilation Versus High-flow Nasal Oxygen in Intensive Care Units

NCT05686850

Post Extubation Respiratory Failure

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 25, 2024Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Gas Exchange Derangement Physiopathology in Critically Ill Patients With COVID-19

Inclusion Criteria

Exclusion Criteria

Driving Pressure During Surgeries With High Risk for Postoperative Pulmonary Complications

Non-Invasive Ventilation Versus High-flow Nasal Oxygen in Intensive Care Units

Global Physiotherapy in ICU Patients With High Risk Extubation Failure

A New Tool for Extubation Readiness in Mechanically Ventilated Patients: Readiness for EXtubation Score

Evaluating the Safety and Performance of the MiniLung Petite Kit in Neonatal and Pediatric Patients With Acute Respiratory and Cardiac Failure

Waveform Capnography Compared to Colorimetric Carbon Dioxide Detection During Tracheal Intubation of Critically Ill Adults