Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
St. Jude Children's Research Hospital
The participant will have 4 PET scans using a novel PET tracer that will help the investigators to quantify when and where in brain neuroinflammation happens following radiation therapy. The participant will receive the first PET scan either before your first dose of radiation therapy or within 2 weeks of the start of radiation therapy. The second PET scan will be obtained before starting chemotherapy. The third scan will be after 1 year of treatment.The final scan will be 1 and a half to 2 years after the start of treatment.The scan process will begin an hour or so after the participant has been given tracer by injection. The entire PET scan process lasts about 2 hours.
Age
8–39
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Participant is at least 8 years of age
Participants with histologically confirmed medulloblastoma and are scheduled to receive 36 Gy craniospinal irradiation
Participant and/or guardian can understand and is willing to sign a written informed consent document according to institutional guidelines
Subjects have either have high-affinity or mixed-affinity TSPO binding sites as determined by the single-nucleotide polymorphism (SNP) rs6971 in the TSPO gene.
You may not be if
Participants with a large pseudomeningocele (\>4 cm in size) at the surgical site, complications from ventricular access (evidenced by hemorrhage and/or enhancement along the catheter), large subdural effusion in the supra-tentorial compartment (\>1 cm in the maximum transverse dimension). All of these are expected to induce inflammation.
Female participants of childbearing age must not be lactating due to theoretical potential harm to the infant from exposure to radiation.
Subjects with low-affinity TSPO binding sites as determined by the single-nucleotide polymorphism (SNP) rs6971 in the TSPO gene.
Pregnant subjects.
Patients needing sedation for the PET scans or optional MRI scans.
Participants with a diagnosis of recurrent medulloblastoma.
Clareo Health | Quantitative Assessment of Radiation-induced Neuroinflammation - A Proof of Principle Study
