Age

18–80

Sex

ALL

Healthy volunteers

Not accepted

Age 18-80 years of age;
CKD with glomerular filtration rate (GFR) between 15-59 ml/min (III and IV stage of CKD) for more than 3 months;
To be able to ambulate \> 300 meters in 6 minutes walk test.

Cognitive dysfunction that prevents the performance of evaluations, as well as an inability to understand and sign the informed consent form;
Intolerance to the electrostimulator and/or alteration of skin sensitivity;
Skin lesions/burns at the electrode placement site;
Patients with stroke in past 6 months with residual limitation to ambulation;
Disabling musculoskeletal disease;
Uncontrolled hypertension (systolic blood pressure \> 230 mmHg and diastolic blood pressure \> 120 mmHg);
Grade III or IV heart failure (NYHA);
Patient with a pacemaker;
Uncontrolled diabetes (fasting blood glucose \> 250 mg/dL);
Unstable angina;
Coronary stent placement in past 3 months;
Recent acute myocardial infarction (two months);
Fever and/or infectious disease;
Peripheral vascular disease in the lower limbs that limits ambulation or deep vein thrombosis;
Chronic obstructive lung disease that limits ambulation or need for oxygen therapy;
Obesity (Body Mass Index≥35);
Patient with active cancer.

Effects of Bioelectric Stimulation in Patients With Non-Dialysis Dependent Chronic Kidney Disease