Investigation of the Gut Microbiota in Acute Myeloid Leukemia Receiving Two Different Induction Therapies

Exclusion Criteria

• •1. Acute promyeloid leukemia;
• •2. AML with central nervous system (CNS) infiltration;
• •3. Any history of chronic intestinal affections (Crohn disease, inflammatory bowel disease, gluten intolerance) or gastrointestinal surgery;
• •4. HIV infection, Chronic hepatitis B virus (HBV) or hepatitis C (HCV) requiring treatment;
• •5. Severe and active infection that is difficult to control and cannot tolerate induction therapy;
• •6. Female who are pregnant, breast feeding or childbearing potential without a negative urine pregnancy test at screen;
• •7. Antibiotic exposure within 30 days before enrollment (carbapenems and/or tigecycline were not included, penicillin, cephalosporins and quinolones could be included)
• •8. Patients reject to participate in the study;
• •9. Patients with severe heart failure (grade 3-4) or patients deemed unsuitable for enrolment by the investigator.