Age

18–any

Sex

ALL

Healthy volunteers

Not accepted

Histologic diagnosis of breast cancer with documentation of ER/PR/HER2 status
Radiographic evidence of stage IV extracranial diease having progressed past first line therapy in HR+/HER2- patients
Radiographic evidence of stage IV extracranial disease in TN and HER2+ patients
Age ≥ 18
Life expectancy ≥ 6 months
Eastern Cooperative Oncology Group performance status 0 to 2
Patients must be able to understand and the willingness to sign an informed consent for study procedures
Stated willingness to comply with all study procedures and availability for the duration of the study

Prior diagnosis or treatment of brain metastases or leptomeningeal disease
Patients with prior history of non-breast cancer malignancies should have no evidence of disease ≥ 2 years
Neurologic symptoms warranting standard screening brain MRI in the judgement of the treating physician at time of enrollment
Indications warranting brain MRI for other neurologic conditions at time of study entry
Contraindication towards MRI imaging with contrast
Chronic kidney disease stage IV or V or end stage renal disease

Study of Screening Brain MRIs in Stage IV Breast Cancer