Male

Metastatic cancer (Stage IV)

Lobular carcinoma as primary diagnosis

Previous ipsilateral breast surgery for benign or malignant disease within two years (this includes implants and breast augmentation)

Subjects with multi-centric disease (histologically diagnosed cancer in two different quadrants of the breast), unless resected in a single specimen

Subjects with bilateral disease (diagnosed cancer in both breasts)

Participating in any other investigational margin assessment study which can influence collection of valid data under this study

Use of cryo-assisted localization

Currently lactating

Current pregnancy

Subjects for whom the specimen margins have been destroyed, damaged, or are otherwise not intact prior to imaging (device arm only) imaging

Wide Field OCT + AI for Positive Margin Rates in Breast Conservation Surgery.