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Acupuncture for Patients With Major Depressive Disorder | Clinical Trials | Clareo Health

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Acupuncture for Patients With Major Depressive Disorder

Acupuncture for Patients With Major Depressive Disorder: Study Protocol of a Randomized Controlled Trial

NCT05106868•Chengdu University of Traditional Chinese Medicine

Summary

Several studies investigating acupuncture for major depressive disorder (MDD) have been carried out. However, investigators found the results were in high heterogeneity and poor methodological quality. Thus, investigators intend to provide high quality of the effectiveness and safety of acupuncture for MDD.

Eligibility

Age

18 - 60 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•1. Right-handed participants aged between 18 to 60 years;
•2. participants diagnosed with mild to moderate major depressive disorder(MDD), and meet the diagnostic criteria of mild to moderate MDD according to the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition (DSM-5);
•3. participants with score of HAMD-24 between 8 to 35;
•4. participants without anti-depressive medication more than 3 months;
•5. participants willing to comply with the study protocol;
•6. participants willing to sign informed consent form.

Exclusion Criteria

•1. participants with severe medical visceral condition and chronic diseases, such as hypertension, coronary heart disease, hyperthyroidism, hypothyroidism or diabetes and other endocrine system diseases;
•2. participants with brain organic diseases: such as birth injury, trauma, encephalitis, tumor, etc.;
•3. participants with Peripheral nerve and muscular system diseases;
•4. participants with severe anxiety, obsessive-compulsive disorder, or a history of mania or hypomania;
•5. Recently taken drugs that may cause mood disorders;
•6. Severe bleeding tendency, allergic constitution and skin disease patients;
•7. pregnant or lactation women;
•8. Persons with visual and hearing disabilities;
•9. Participants with pacemakers, deep brain stimulators, vagus nerve stimulators, metal internal fixators, etc
•10. participate in other clinical trials at the same time

Key Dates

Start Date

November 1, 2021

Primary Completion Date

December 30, 2022

Completion Date

June 30, 2023

Last Updated

November 4, 2021

Enrollment

123

ESTIMATED participants

Conditions

Major Depressive Disorder

Interventions

acupuncture

DEVICE

Contacts

Zhong Zheng, PhD

CONTACT

18980601861 zhengzhong1963@163.com

Rongjiang Jin

CONTACT

cdzyydxjrj@126.com

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: November 4, 2021Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Acupuncture for Patients With Major Depressive Disorder

Inclusion Criteria

Exclusion Criteria

A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder

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