1. Participating in another interventional Trial;

2. Contraindication to arterial blood pressure monitoring;

3. Subjects with a physical site area too limited for proper Sensor placement

4. Serum creatine \> 175 μmol/L (\>2.0 mg/dL) or CKD stage \> 3A

5. Scheduled for intracranial surgery with permissive hypotension;

6. Patient who is confirmed to be pregnant and/or nursing mothers;

7. Patients with an intra-aortic balloon pump (IABP) or ventricular assist device(s);

8. Have a condition that precludes routine or tight blood pressure management such as surgeon request for relative hypotension;

9. Emergency surgery;

10. Require beach-chair positioning;

11. Scheduled for cardiac surgeries

12. Have previously participated in the SMART-BP trial.

Hypotension Prediction Index (HPI) SMART-BP Trial