A Study of Lu AF82422 in Participants With Multiple System Atrophy

Inclusion Criteria

• •The participant is diagnosed with possible or probable MSA of the multiple system atrophy parkinsonian type (MSA-P) or multiple system atrophy cerebellar type (MSA-C) sub-type at the Screening Visit.
• •The participant had onset of motor and/or autonomic (orthostatic or urinary) MSA symptoms within 5 years prior to the Screening Visit in the judgement of the investigator.
• •The participant has an UMSARS Part I score ≤16 (omitting item 11 on sexual function) at the Screening Visit.
• •The participant has a cognitive performance evaluated by the Montreal Cognitive Assessment (MoCA) with a score ≥22 at the Screening Visit.
• •Open-label Extension Entry Criteria
• •The participant has completed the EoT Visit and did not withdraw in the DBP.
• •The participant has consented to participate in the OLE.
• •The participant has completed the DBP within the last 5 months and will be enrolled into the OLE no later than end of Q1 2024.
• •The participant is, in the Investigator's opinion, likely to comply with the protocol.
• •The participant has not received any other Investigational product since the EOoTDBP Visit.