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WITHDRAWNPhase 4NCT05101928

Ozurdex Monotherapy Trial

This study will investigate the efficacy and safety of OZURDEX® (dexamethasone intravitreal implants; DEX, Allergan, Inc. Irvine, CA) as monotherapy for the treatment of non-infectious intermediate-, ...

Lead sponsor: Ottawa Hospital Research Institute•1 locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Ottawa Hospital Research Institute

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Age ≥18 years
•Diagnosis of non-infectious intermediate, posterior, or panuveitis in at least one eye
•Active uveitic disease at Screening/Baseline defined by the presence of at least 1 of the following parameters: 1) Active, inflammatory, chorioretinal and/or inflammatory retinal vascular lesion 2) ≥ 1+ vitreous haze (NEI/SUN criteria)

Exclusion Criteria

•Presence of isolated anterior uveitis
•Evidence of macular edema due to diabetes, retinal vein occlusion or any other ocular conditions
•Confirmed or suspected active ocular disease or infections
•Intraocular surgery in the past 6 months
•History of glaucoma
•Intraocular pressure (IOP) of \>21 mmHg at Screening/Baseline or confirmed normal-tension glaucoma
•Intravitreal or periocular injection within 6 months prior to screening.
•Unable to tolerate systemic corticosteroids
•Prior topical corticosteroid within 1 month of screening
•Prior non-steroidal anti-inflammatory, systemic steroids, or immunomodulatory therapy (e.g. methotrexate) within 1 month of screening
•For women: pregnant or breast feeding, or planning to become pregnant while enrolled in the study

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: March 12, 2025Terms

Trial snapshot

StatusWITHDRAWN

PhasePHASE4

Enrollment—

Start dateNov 2021

Last updatedMar 12, 2025

Condition

Uveitis, Posterior Uveitis, Intermediate Panuveitis

Locations shown

Ottawa Hospital Research Institute - Vision Research Centre

Ottawa, Ontario

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 12, 2025Data synced to Clareo: May 25, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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