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N-acetylcysteine for Attenuation of COVID Symptomatology
The objective of this study is to determine whether oral NAC is effective at attenuating COVID-19 disease symptom severity and duration of symptoms.
STUDY DESIGN: Randomized double-blinded placebo-controlled trial ELIGIBILITY Inclusion criteria: * age 18 years and older * participants will need daily access to use of a smartphone for at least six weeks from time of enrollment * Positive COVID-19 test within 10 days of date of enrollment * not already hospitalized for treatment of COVID Exclusion criteria: * pregnant * already hospitalized for treatment of COVID PROTOCOL * 50:50 randomization: half of participants will take NAC, half will take placebo * Participants will take NAC/placebo following this outpatient protocol: * 2400 mg x 1 PO then * 1200 mg PO BID x 14 days * Participants will complete an online symptom-tracker for six weeks (daily for three weeks, weekly for three weeks)
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
Yes
Cambridge Health Alliance
Everett, Massachusetts, United States
Start Date
March 31, 2024
Primary Completion Date
December 31, 2024
Completion Date
February 1, 2025
Last Updated
August 7, 2023
200
ESTIMATED participants
N-acetylcysteine
DRUG
Placebo
OTHER
Lead Sponsor
Cambridge Health Alliance
Collaborators
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.
View ClinicalTrials.gov Terms and ConditionsNCT06355232