Effect of Inulin on Gut Microbiota and Gut Barrier in Chronic Kidney Disease

Inclusion Criteria

• •Men and women in a ratio of 1:1
• •Age 18-75 years
• •Body mass index 25.0 - 39.9 kg/m\^2
• •End-stage kidney disease, which has been treated regularly with hemodialysis for at least 3 months
• •* Age range was changed from 18-70 to 18-75 years
• •* BMI range was changed from 18.5 - 34.9 to 25.0 - 39.9 kg/m\^2
• •The intervention scheme was adapted to increase patient adherence
• •* A 7-day adaption phase with half of the dose (15 grams per day) at the start of the intervention was introduced, changing treatment duration from 28 to 35 days
• •Changes applied in January 2024 according to amendment no. 2:
• •* BMI range was changed from 25 - 39,9 to 18,5 - 39,9 kg/m²
• •Last visit was brought foward by 4 weeks.