Lead Sponsor

Seoul National University Hospital

Age

19 - No limit years

Sex

ALL

Healthy Volunteers

Yes

•Males or females ≥ 19 years of age at time of consent
•Have a diagnosis of RA per ACR criteria
•Must understand and voluntarily sign an informed consent form including writing consent for data protection
•Stable doses of methotrexate over the preceding 6 weeks

•Pregnant or lactating females
•Previous anaphylactic response to vaccine components or to egg.
•Acute infection with T \>38°C at the time of vaccination
•History of Guillain-Barre syndrome or demyelinating syndromes
•Blood transfusion within 6 months
•Any other rheumatic disease such as systemic lupus erythematosus, mixed connective tissue disease, dermatomyositis/polymyositis, and vasculitis except for secondary Sjogren's disease
•Any condition including laboratory abnormality which places the subject at unacceptable risk
•Subjects who decline to participate