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Combined Flow-pressure Study of Cerebrospinal Circulation Using CSF Perfusion Tests and Phase-contrast MRI - Reversible Dementia Substudy
Normal pressure hydrocephalus (NPH) can cause a type of dementia. However, this type of dementia is the only one that is reversible. To treat this dementia it is necessary to evacuate the accumulation of CSF from the brain to another body cavity using a device called a shunt. But the implantation of this shunt is only effective when the cause of the pathology is an alteration of the normal circulation of the CSF. To diagnose these patients, morphological MRI and lumbar puncture are standard approaches used but remain perfectible in diagnostic terms. The main objective is to build a new model of the interaction of intracranial pressures and fluids in order to obtain a new parameter allowing to obtain information on the cerebral biomechanics.
Age
55 - No limit years
Sex
ALL
Healthy Volunteers
No
CHU Amiens
Salouël, France
Start Date
September 1, 2021
Primary Completion Date
September 1, 2023
Completion Date
September 1, 2024
Last Updated
April 10, 2024
73
ACTUAL participants
Flow MRI
OTHER
PERFUSION TEST
OTHER
Lead Sponsor
Centre Hospitalier Universitaire, Amiens
Collaborators
NCT07053631
NCT06979999
Data Source & Attribution
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