Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Age
0–18
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
1. Informed consent signed by the patient (ages 14 to 18) and / or his legal representative (ages 0 to 18).
2. The patient has an indication for allogeneic transplantation of hematopoietic stem cells established in accordance with the current regulatory framework
3. Planned HSCT selective immunomagnetic depletion of alpha/betta T lymphocytes
4. Karnovsky or Lansky index more than 50%
5. Life expectancy at least 4 weeks
6. Heart function: ejection fraction of at least 40%
7. Consent to continue follow-up for 5 years
You may not be if
1. Acute viral hepatitis or acute HIV infection
2. Hypoxemia with SaO2 \<90%
3. Bilirubin\> 3 norms
4. Creatinine\> 3 norms
5. Pregnancy and lactation
6. Severe uncontrolled infection
7. Severe (\>?) pathology of the central nervous system (epilepsy, dementia, organic damage to the central nervous system, psychosis)
Clareo Health | Ex-vivo Primed Memory Donor Lymphocyte Infusion to Boost Anti-viral Immunity After T-cell Depleted HSCT
