Using Genetic Profile to Determine the Treatment for Patients With Ovarian Cancer Who Previously Received a PARP-inhibitor

Exclusion Criteria

• •Treatment with an investigational (other than PARP inhibitor) drug within 30 days and treatment with PARP inhibitor within 14 days prior to the first dose of study medication.
• •Major surgery within 4 weeks of registration or ongoing clinically significant post-surgical complications.
• •Patients with current or are at high-risk of developing fistula, or any other gastrointestinal disorders likely to interfere with absorption of the study medication.
• •Patients with current or history of bowel obstruction within the last 3 months.
• •Untreated unstable brain or leptomeningeal metastases.
• •Greater than +1 proteinuria on two consecutive dipsticks within 14 days of registration.
• •Unresolved toxicity of \> grade 1 from previous anti-cancer therapy (including radiotherapy).
• •.History of poorly controlled hypertension or resting blood pressure \>140/90 mmHg in the presence or absence of a stable regimen of anti-hypertensive therapy within 7 days of registration.
• •Mean QTc \>470 msec in screening electrocardiograms within 7 days of registration or history of familial long QT syndrome.
• •Any evidence of severe or uncontrolled diseases such as but not limited to unstable or uncompensated respiratory, cardiac, hepatic, renal disease or psychiatric illness/social situations that would limit compliance with study requirements.
• •History of allergic reactions attributed to compounds of similar chemical or biologic composition to bevacizumab, paclitaxel, dostarlimab, or niraparib.
• •Patients who have received prior weekly paclitaxel in the recurrent ovarian cancer setting.
• •Patients who have received prior PD-1 inhibitor for ovarian cancer.
• •Active autoimmune disease that has required systemic treatment in the past 2 years.
• •History of interstitial lung disease.
• •Patients with myelodysplastic syndrome/acute myeloid leukemia
• •Previous allogenic bone marrow transplant.
• •Immuno-compromised patients, e.g., patients who are known to be serologically positive for human immunodeficiency virus (HIV), patients with known active hepatitis (i.e., hepatitis B or C).
• •Patients with significant hemorrhage (\>30 mL bleeding/episode in previous 3 months) or hemoptysis (\>5 mL fresh blood in previous 4 weeks).
• •Patients who have had recent (within 2 weeks of registration, or until any wound has completely healed) major thoracic or abdominal surgery prior to study start, or a surgical incision that is not fully healed.
• •History of stroke or transient ischemic attack within six months.
• •Patients that are receiving other anti-cancer therapy (except patient currently progressing on treatment with PARP inhibitor), radiotherapy, biological therapy or other novel agent prior to start of study treatment.
• •Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or study drug administration, or may interfere with the interpretation of study results, and in the judgment of the investigator would make the participant inappropriate for entry into the study.
• •History of other primary second malignancies (except for adequately treated cutaneous basal or squamous cell carcinoma or carcinoma in situ) within \< 3 years.