Breast Cancer BRCA1 Carriers: a Pilot Study

Exclusion Criteria

• •1. Patients may not have used progesterone-only contraceptives (i.e. Depo- Provera) within the last 6 months. Combination estrogen/progesterone or estrogen only contraceptives are allowed.
• •2. Presence of an intrauterine device
• •3. Personal history of breast or ovarian cancer
• •4. Active heavy smoker, defined as 10 or more cigarettes per day on any occasion in the past 30 days
• •5. Uncontrolled chronic medical condition, including insulin dependent diabetes, NYHA class II, III or IV congestive heart failure, unstable angina, history of myocardial infarction, chronic pulmonary conditions including uncontrolled asthma (symptoms \> 2 days/week) or dyspnea requiring oxygen, peripheral vascular disease, symptomatic anemia, uncontrolled psychiatric conditions, chronic kidney disease, or liver disease (cirrhosis, NAFLD, etc.)
• •6. Requiring ongoing therapy with strong CYP3A4 inhibitor, steroids, or immunosuppressants (i.e. tacrolimus, cyclosporine, etc.). Please see appendix for full list of excluded co-medications. If questions, please ask the PI.
• •7. History of life- threatening allergic reaction to local anesthesia (lidocaine, xylocaine).
• •8. Contraindications including but not limited to allergic reactions to mifepristone or other prostaglandins, or inherited porphyrias
• •9. For the purposes of invasive breast biopsies, women must not be receiving therapeutic anticoagulation or antiplatelet agents