High Dose-Rate Brachytherapy for the Treatment of Both Primary and Secondary Unresectable Liver Malignancies

Exclusion Criteria

• •Active infectious disease
• •Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, interstitial lung disease, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
• •Patients with polymetastatic disease with the exception of those patients who may benefit from therapy addressing local complications directly related to the target lesion diminishing quality of life such as pain, vascular/biliary occlusion, and liver disfunction
• •Pregnancy (sexually active patients must be on birth control while participating in this study)
• •Child-Pugh class C
• •Total serum bilirubin \> 2 mg/dl
• •Platelet count \< 50,000/ul
• •International normalized ratio (INR) \> 1.5