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Cardiac MRI for the Detection of Myocardial Injury Following Acute Kidney Injury | Clinical Trials | Clareo Health

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Cardiac MRI for the Detection of Myocardial Injury Following Acute Kidney Injury

Multiparametric Cardiac MRI for the Detection and Quantification of Myocardial Injury Following Acute Kidney Injury (Cardiorenal Syndrome Type 3)

NCT05034588•University Hospital, Bonn

View on ClinicalTrials.gov

Summary

The aim of this clinical prospective study is to assess structural and functional myocardial changes in patients after acute kidney injury (Cardiorenal syndrome type 3) and intensive care stay by multiparametric cardiac MRI.

Detailed Description

The aim of the study is to demonstrate any differences in myocardial structure and function using multiparametric cardiac MRI in patients after acute kidney injury (Cardiorenal syndrome type 3) and intensive care stay and subsequent convalescence compared to a control group with intensive care stay but without kidney injury. Furthermore, the correlation between clinical disease severity and cardiac involvement will be investigated.

Eligibility

Age

18 - 60 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. acute kidney injury and convalescence (GFR \> 45 ml/min/1.73m²).
•2. patients who are 18 years of age or older

Exclusion Criteria

•1. underlying cardiac disease, e.g. known myocardial infarction, previous myocarditis, congenital heart disease, cardiomyopathies of other causes
•2. known underlying disease wit potential cardiac involvement, e.g. storage disease (e.g. hemochromatosis, Fabry disease), inflammatory (e.g. sarcoidosis), endocrinological (e.g. diabetes mellitus, hyper-/hypothyroidism), autoimmune (e.g. systemic lupus erythematosus, dermatomyositis, rheumatoid arthritis), therapeutic (chemotherapy).
•3. patients with persistent renal failure and GFR \< 45 ml/min/1.73m²
•4. allergy to contrast media
•5. patients who are using a intrauterinpessare for contraception
•6. pregnant and breastfeeding women
•7. patients with contraindications for MRI due to implants

Locations (2)

University Hospital Bonn, Clinic for Diagnostic and Interventional Radiology

Bonn, North Rhine-Westphalia, Germany

University Hospital Bonn, Department of Anesthesiology and Intensive Care Medicine

Bonn, North Rhine-Westphalia, Germany

Key Dates

Start Date

April 7, 2021

Primary Completion Date

July 31, 2022

Completion Date

December 31, 2023

Last Updated

September 5, 2021

Enrollment

ESTIMATED participants

Conditions

Acute Kidney InjuryCardio-Renal SyndromeCardiomyopathies

Interventions

Cardiac magnetic resonance scan

DIAGNOSTIC_TEST

Contacts

Julian A Luetkens, PD Dr. med.

CONTACT

+49 228 287-15960 julian.luetkens@ukbonn.de

Alexander Isaak, PD Dr. med.

CONTACT

+49 228 287-15960 alexander.isaak@ukbonn.de

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: September 5, 2021Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Cardiac MRI for the Detection of Myocardial Injury Following Acute Kidney Injury

Inclusion Criteria

Exclusion Criteria

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