Dose-painting Radiation for LA-NSCLC

Exclusion Criteria

• •1. There is evidence of distant metastasis (M1, AJCC 8th edition \[Rice et al., 2017\]);
• •2. There is pleural effusion, pericardial effusion or ascites that is not clinically controlled and requires repeated drainage or medical intervention (within 2 weeks before randomization);
• •3. Intolerance or resistance to the chemotherapy, targeted, and immunotherapy specified in the experimental protocol;
• •4. Have received radiotherapy and surgical treatment;
• •5. There were other active malignant tumors ≤ 2 years before enrollment, except for the specific cancers under study in this study and locally recurring cancers that have been cured (eg, resected basal cell or squamous cell skin cancer, superficial Bladder cancer, carcinoma in situ of the cervix or breast);
• •6. A history of interstitial lung disease, non-infectious pneumonia or uncontrolled systemic diseases, including pulmonary fibrosis, acute lung diseases, etc.;
• •7. Has suffered from other malignant tumors;
• •8. Subjects who have received other drug trials within the past month;
• •9. Pregnant or lactating women and women who refuse contraception during the treatment observation period;
• •10. People with a history of severe allergies or idiosyncratic physique;
• •11. Those with a history of severe lung or heart disease;
• •12. Refusal or inability to sign the informed consent to participate in the trial;
• •13. Drug or alcohol addicts;
• •14. Personality or mental illness, lack of capacity for civil conduct or limited capacity for civil conduct.